Category: Microfluidic Devices
Microfluidic devices enable the modeling of large systems or system components on a smaller, micron scale, increasing the potential for automation and portability, decreasing experimental measurement times, and decreasing experimental costs. The following papers discuss the use of these devices in many areas of research, such as proteomics, biology, kinetics of chemical processes, and surface modification.
Articles- Dong, Yi, K. Scott Phillips, Quan Cheng. "Immunosensing of Staphylococcus Enterotoxin B (SEB) in Milk with PDMS Microfluidic Systems Using Reinforced Supported Bilayer Membranes (r-SBMs)." Lab on a Chip (2006) 6: 675-681.
- Koyama, Sachiko, Dragos Amarie, Helena A. Soini, Milos V. Novotny, Stephen C. Jacobson. "Chemotaxis Assays of Mouse Sperm on Microfluidic Devices." Anal. Chem. (2006) 78: 3354-3359.
- Li, Michelle W., Bryan H. Huynh, Matthew K. Hulvey, Susan M. Lunte, R. Scott Martin. "Design And Characterization of Poly(Dimethylsiloxane)-Based Valves for Interfacing Continuous-Flow Sampling to Microchip Electrophoresis." Anal. Chem. (2006) 78(4): 1042-1051.
- Park, Jang-Ung, Matthew. A. Meitl, Seung-Hyun Hur, Monica L. Usrey, Michael S. Strano, Paul J. A. Kenis, John A. Rogers. "In Situ Deposition and Patterning of Single-Walled Carbon Nanotubes by Laminar Flow and Controlled Flocculation in Microfluidic Channels." Angew. Chem. Int. Ed. (2006) 45(4): 581-585.
- Song, Yong-Ak, Stephanie Hsu, Anna L. Stevens, Jongyoon Han. "Continuous-Flow pI-Based Sorting of Proteins And Peptides in a Microfluidic Chip Using Diffusion Potential." Anal. Chem. (2006) 78: 3528-3536.
- Steinhaus, Benjamin, Patrick T. Spicer, Amy Q. Shen. "Droplet Size Effects on Film Drainage Between Droplet and Substrate." Langmuir (2006) 22: 5308-5313.
- Chung, Bong Geun, Lisa A. Flanagan, Seog Woo Rhee, Philip H. Schwartz, Abraham P. Lee, Edwin S. Monuki, Noo Li Jeon. "Human Neural Stem Cell Growth and Differentiation in a Gradient-Generating Microfluidic Devices." Lab on a Chip (2005) 5: 401-405.
- Cohen, Adam E., W. E. Moerner. "An All-Glass Microfluidic Cell for the ABEL Trap: Fabrication and Modeling." Proceedings of SPIE: Optical Trapping and Optical Micromanipulation II (2005) 5930: 59300S1-59300S8.
- Daniel, Susan, Manoj K. Chaudhury, P.-G. de Gennes. "Vibration-Actuated Drop Motion on Surfaces for Batch Microfluidic Processes." Langmuir (2005) 21: 4240-4248.
- Dendukuri, Dhananjay, Kim Tsoi, T. Alan Hatton, Patrick S. Doyle. "Controlled Synthesis of Nonspherical Microparticles Using Microfluidics." Langmuir (2005) 21: 2113-2116.
- Dhopeshwarkar, Rahul, Li Sun, Richard M. Crooks. "Electrokinetic Concentration Enrichment Within a Microfluidic Device Using a Hydrogel Microplug." Lab on a Chip (2005) 5: 1148-1154.
- Dusseiller, Marc R., Brigitte Niederberger, Brigitte Städler, Didier Falconnet, Marcus Textor, Janos Vörös. "A Novel Crossed Microfluidic Device for the Precise Positioning of Proteins and Vesicles." Lab on a Chip (2005) 5: 1387-1392.
- El-Ali, Jamil, Suzanne Gaudet, Axel Günther, Peter K. Sorger, Klavs F. Jensen. "Cell Stimulus And Lysis in a Microfluidic Device with Semented Gas-Liquid Flow." Anal. Chem. (2005) 77: 3629-3636.
- Fu, Qiang, Jie Liu. "Integrated Single-Walled Carbon Nanotube Microfluidic Devices for the Study of the Sensing Mechanism of Nanotube Sensors." J. Phys. Chem. B (2005) 109(28): 13406-13408.
- García, Carlos D., Guenter Engling, Pierre Herckes, Jeffrey L. Collett Jr., Charles S. Henry. "Determination of Levoglucosan from Smoke Samples Using Microchip Capillary Electrophoresis with Pulsed Amperometric Detection." Environ. Sci. Technol. (2005) 39: 618-623.
- Gunther, Axel, Manish Jhunjhunwala, Martina Thalmann, Martin A. Schmidt, Klavs F. Jensen. "Micromixing of Miscible Liquids in Segmented Gas-Liquid Flow." Langmuir (2005) 21: 1547-1555.
- Hompesch, Richard W., Carlos D. Garcıa, David J. Weiss, Jorge M. Vivancod, Charles S. Henry. "Analysis of Natural Flavonoids by Microchip-Micellar Electrokinetic Chromatography with Pulsed Amperometric Detection." The Analyst (2005) 130: 694-700.
- Jiang, Xingyu, Qiaobing Xu, Stephan K. W. Dertinger, Abraham D. Stroock, Tzung-may Fu, George M. Whitesides. "A General Method for Patterning Gradients of Biomolecules on Surfaces Using Microfluidic Networks." Anal. Chem. (2005) 77: 2338-2347.
- Kim, Kyu Sung, Je-Kyun Park. "Magnetic Force-Based Multiplexed Immunoassay Using Superparamagnetic Nanoparticles in Microfluidic Channel." Lab on a Chip (2005) 5: 657-664.
- Liu, Jikun, Xuefei Sun, Milton L. Lee. "Surface-Reactive Acrylic Copolymer for Fabrication of Microfluidic Devices." Anal. Chem. (2005) 77: 6280-6287.
- Niu, Xize, Weijia Wen, Yi-Kuen Lee. "Electrorheological-Fluid-Based Microvalves." Appl. Phys. Lett. (2005) 87: 243501(1-3).
- Phillips, K. Scott, Quan Cheng. "Microfluidic Immunoassay for Bacterial Toxins with Supported Phospholipid Bilayer Membranes on PDMS." Anal. Chem. (2005) 77: 327-334.
- Rhee, Seog Woo, Anne M. Taylor, Christina H. Tu, David H. Cribbs, Carl W. Cotman, Noo Li Jeon. "Patterned Cell Culture Inside Microfluidic Devices." Lab on a Chip (2005) 5: 102-107.
- Toepke, Michael W., Paul J. A. Kenis. "Multilevel Microfluidics Via Single-Exposure Photolithography." J. Am. Chem. Soc. (2005) 127: 7674-7675.
- Xuan, Xiangchun, Bo Xu, Dongqing Li. "Accelerated Particle Electrophoretic Motion And Separation in Converging-Diverging Microchannels." Anal. Chem. (2005) 77: 4323-4328.
- Yap, Belinda, Roger D. Kamm. "Mechanical Deformation of Neutrophils Into Narrow Channels Induces Pseudopod Projection and Changes in Biomechanical Properties." J. Appl. Physiol. (2005) 198: 1930-1939.
- Burdick, Jason A., Ali Khademhosseini, Robert Langer. "Fabrication of Gradient Hydrogels Using a Microfluidics/ Photopolymerization Process." Langmuir (2004) 20(13): 5153-5156.
- Chao, Wen-Chi, John Collins, Szu-Wen Wang, G. P. Li, Mark Bachman, Abraham P. Lee. "Control of Concentration and Volume Gradients in Microfluidic Droplet Arrays for Protein Crystallization Screening." Conference Proceedings: 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (2004) 1(4): 2623-2626.
- Erickson, David, Xuezhu Liu, Ulrich Krull, Dongqing Li. "Electrokinetically Controlled Dna Hybridization Microfluidic Chip Enabling Rapid Target Analysis." Anal. Chem. (2004) 76: 7269-7277.
- García, Carlos D., Charles S. Henry. "Enhanced Determination of Glucose by Microchip Electrophoresis with Pulsed Amperometric Detection." Analytica Chimica Acta (2004) 508: 1-9.
- Garcia, Carlos D., Charles S. Henry. "Direct Detection of Renal Function Markers Using Microchip CE with Pulsed Electrochemical Detection." Analyst (2004) 129: 579-584.
- Ginn, Brent T., Bettina Steinbock, Murat Kahveci, Oliver Steinbock. "Microfluidic Systems for the Belousov-Zhabotinsky Reaction." J. Phys. Chem. A (2004) 108: 1325-1332.
- Jeon, Seokwoo, Jang-Ung Park, Ray Cirelli, Shu Yang, Carla E. Heitzman, Paul V. Braun, Paul J. A. Kenis, John A. Rogers. "Fabricating Complex Three-Dimensional Nanostructures with High-Resolution Conformable Phase Masks." Proc. Natl. Ac. Sci. (2004) 101(34): 12428-12433.
- Khademhosseini, Ali, Kahp Y. Suh, Sangyong Jon, George Eng, Judy Yeh, Guan-Jong Chen, Robert Langer. "A Soft Lithographic Approach to Fabricate Patterned Microfluidic Channels." Anal. Chem. (2004) 76: 3675-3681.
- Lin, Francis, Connie Minh-Canh Nguyen, Shur-Jen Wang, Wajeeh Saadi, Steven P. Gross, Noo Li Jeon. "Effective Neutrophil Chemotaxis is Strongly Influenced by Mean IL-8 Concentration." Biochem. Biophys. Res. Commun. (2004) 319: 576-581.
- Lin, Francis, Wajeeh Saadi, Seog Woo Rhee, Shur-Jen Wang, Sukant Mittal, Noo Li Jeon. "Generation of Dynamic Temporal and Spatial Concentration Gradients Using Microfluidic Devices." Lab on a Chip (2004) 4: 164-167.
- Liu, Daojun, Robbyn K. Perdue, Li Sun, Richard M. Crooks. "Immobilization of DNA onto Poly(Dimethylsiloxane) Surfaces and Application to a Microelectrochemical Enzyme-Amplified DNA Hybridization Assay." Langmuir (2004) 20(14): 5905-5910.
- Liu, Yan, Jonathan A. Vickers, Charles S. Henry. "Simple And Sensitive Electrode Design for Microchip Electrophoresis/Electrochemistry." Anal. Chem. (2004) 76: 1513-1517.
- Russo, A. Peter, Scott T. Retterer, Andrew J. Spence, Michael S. Isaacson, Lori A. Lepak, Michael G. Spencer, David L. Martin, Robert MacColl, James N. Turner. "Direct Casting of Polymer Membranes Into Microfluidic Devices." Sep. Sci. Technol. (2004) 39(11): 2515-2530.
- Stroock, Abraham D., Gregory J. McGraw. "Investigation of the Staggered Herringbone Mixer with a Simple analytical Model." Phil. Trans. R. Soc. Lond. A (2004) 362: 971-986.
- Tabeling, P., M. Chabert, A. Dodge, C. Jullien, F. Okkels. "Chaotic Mixing in Cross-Channel Micromixers: One Contribution of 11 to a Theme 'Transport and Mixing at the Microscale'." Philos. T. R. Soc. A (2004) 362(1818): 987-1000.
- García, Carlos D., DeGail J. Hadley, W. William Wilson, Charles S. Henry. "Measuring Protein Interactions by Microchip Self-Interaction Chromatography." Biotechnol. Prog. (2003) 19: 1006-1010.
- García, Carlos D., Yan Liu, Paul Anderson, Charles S. Henry. "Versatile 3-Channel High-Voltage Power Supply for Microchip Capillary Electrophoresis." Lab on a Chip (2003) 3: 324-328.
- Gifford, Sean C., Michael G. Frank, Jure Derganc, Christopher Gabel, Robert H. Austin, Tatsuro Yoshida, Mark W. Bitensky. "Parallel Microchannel-Based Measurements of Individual Erythrocyte Areas and Volumes." Biophys. J. (2003) 84: 623-633.
- Heo, Jinseok, K. Joseph Thomas, Gi Hun Seong, Richard M. Crooks. "A Microfluidic Bioreactor Based on Hydrogel-Entrapped E. Coli: Cell Viability, Lysis, and Intracellular Enzyme Reactions." Anal. Chem. (2003) 75: 22-26.
- Li, Cheuk-Wing, Chung Nam Cheung, Jun Yang, Chi Hung Tzang, Mengsu Yang. "PDMS-based microfluidic device with multi-height structures fabricated by single-step photolithography using printed circuit board as masters." Analyst (2003) 128: 1137-1142.
- Mao, Hanbin, Paul S. Cremer, Michael D. Manson. "A Sensitive, Versatile Microfluidic Assay for Bacterial Chemotaxis." Proc. Natl. Ac. Sci. (2003) 100(9): 5449-5454.
- Osbourn, Damon M., Craig E. Lunte. "On-Column Electrochemical Detection for Microchip Capillary Electrophoresis." Anal. Chem. (2003) 75: 2710-2714.
- Son, Sang Uk, Yo Han Choi, Seung S. Lee. "Micro-Cell Counter Using Photoconductance of Boron Diffused Resistor (BDR)." Sens. Actuators, A (2003) 111: 100-106.
- Song, Helen, Rustem F. Ismagilov. "Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents." J. Am. Chem. Soc. (2003) 125: 14613-14619.
- Zhang, Ying, Aaron T. Timperman. "Integration of Nanocapillary Arrays into Microfluidic Devices for Use as Analyte Concentrators." Analyst (2003) 128: 537-542.
- Dertinger, Stephan K. W., Xingyu Jiang, Zhiying Li, Venkatesh N. Murthy, George M. Whitesides. "Gradients of Substrate-Bound Laminin Orient Axonal Specification of Neurons." Proc. Natl. Ac. Sci. (2002) 99(20): 12542-12547.
- Kim, M. J., A. Beskok, K. D. Kihm. "Electro-Osmosis-Driven Micro-Channel Flows: a Comparative Study of Microscopic Particle Image Velocimetry Measurements and Numerical Simulations." Exp. Fluids (2002) 33: 170-180.
- Mao, Hanbin, Tinglu Yang, Paul S. Cremer. "A Microfluidic Device with a Linear Temperature Gradient for Parallel and Combinatorial Measurements." J. Am. Chem. Soc. (2002) 124: 4432-4435.
- Mao, Hanbin, Tinglu Yang, Paul S. Cremer. "Design and Characterization of Immobilized Enzymes in Microfluidic Systems." Anal. Chem. (2002) 74: 379-385.
- McDonald, J. Cooper, Michael L. Chabinyc, Steven J. Metallo, Janelle R. Anderson, Abraham D. Stroock, George M. Whitesides. "Prototyping of Microfluidic Devices in Poly(Dimethylsiloxane) Using Solid-Object Printing." Anal. Chem. (2002) 74: 1537-1545.
- Ro, Kyung Won, Kwanseop Lim, Ho Kim, Jong Hoon Hahn. "Poly(Dimethylsiloxane) Microchip for Precolumn Reaction and Micellar Electrokinetic Chromatography of Biogenic Amines." Electrophoresis (2002) 23: 1129-1137.
- Seong, Gi Hun, Wei Zhan, Richard M. Crooks. "Fabrication of Microchambers Defined by Photopolymerized Hydrogels and Weirs Within Microfluidic Systems: Application to DNA Hybridization." Anal. Chem. (2002) 74: 3372-3377.
- Splawn, Bryan G., Fred E. Lytle. "On-Chip Absorption Measurements Using an Integrated Waveguide." Anal. Bioanal. Chem. (2002) 373: 519-525.
- Chabinyc, Michael L., Daniel T. Chiu, J. Cooper McDonald, Abraham D. Stroock, James F. Christian, Arieh M. Karger, George M. Whitesides. "An Integrated Fluorescence Detection System in Poly(Dimethylsiloxane) for Microfluidic Applications." Anal. Chem. (2001) 73: 4491-4498.
- Dutta, Prashanta, Min Jun Kim, Kenneth D. Kihm, Ali Beskok. "Electroosmotic Flow in a Grooved Micro-Channel Configuration: a Comparitive Study of Micro-PIV Measurments and Numerical Simulations." 2001 ASME International Mechanical Engineering Congress and Exposition (2001) Nov. 11-16, New York, 2001: 677-683.
- Hovis, Jennifer S., Steven G. Boxer. "Patterning and Composition Arrays of Supported Lipid Bilayers by Microcontact Printing." Langmuir (2001) 17: 3400-3405.
- Kim, Jin-Sung, Daniel P. Knapp. "Miniaturized Multichannel Electrospray Ionization Emitters on Poly(Dimethylsiloxane) Microfluidic Devices." Electrophoresis (2001) 22: 3993-3999.
- McDonald, J. Cooper, Steven J. Metallo, George M. Whitesides. "Fabrication of a Configurable, Single-Use Microfluidic Device." Anal. Chem. (2001) 73: 5645-5650.
- Yang, Tinglu, Seung-yong Jung, Hanbin Mao, Paul S. Cremer. "Fabrication of Phospholipid Bilayer-Coated Microchannels for On-Chip Immunoassays." Anal. Chem. (2001) 73: 165-169.
- Anderson, Janelle R., Daniel T. Chiu, Rebecca J. Jackman, Oksana Cherniavskaya, J. Cooper McDonald, Hongkai Wu, Sue H. Whitesides, George M. Whitesides. "Fabrication of Topologically Complex Three-Dimensional Microfluidic Systems in PDMS by Rapid Prototyping." Anal. Chem. (2000) 72: 3158-3164.
- Arias, Francisco, Paul J. A. Kenis, Bing Xu, Tao Deng, Olivier J. A. Schueller, Yuki Sugimura, Anthony G. Evans, George M. Whitesides. "Fabrication and Characterization of Microscale Sandwich Beams." J. Mater. Res. (2000) 16(2): 597-605.
- Liu, Yan, Joseph C. Fanguy, Justin M. Bledsoe, Charles S. Henry. "Dynamic Coating Using Polyelectrolyte Multilayers for Chemical Control of Electroosmotic Flow in Capillary Electrophoresis Microchips." Anal. Chem. (2000) 72: 5939-5944.
- Duffy, David C., Olivier J. A. Schueller, Scott T. Brittain, George M. Whitesides. "Rapid Prototyping of Microfluidic Switches in Poly(Dimethyl Siloxane) and Their Actuation by Electro-Osmotic Flow." J. Micromech. Microeng. (1999) 9: 211-217.
- Duffy, David C., J. Cooper McDonald, Olivier J. A. Schueller, George M. Whitesides. "Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)." Anal. Chem. (1998) 70: 4974-4984.
Patents- Wilson, Wilbur W., Charles S. Henry, Carlos D. Garcia. "Micro-Fluidic Device for Measuring Osmotic Second Virial Coefficients." Patent US6974678 B2. Dec. 13, 2005 (granted). Apr. 08, 2004 (published).
- Ismagilov, Rustem F., Joshua David Tice, Helen Song. "Device and Method for Pressure-Driven Plug Transport and Reaction." Patent US20050272159 A1. Dec. 08, 2005 (published).
- Stutzmann, Natalie, Theodorus Tervoort, Cees Bastiaansen, Paul Smith. "The Method for Microstructuring Polymer Supported Materials." Patent WO0160589 A1. Aug. 24, 2005 (published).
- Hubbell, Jeffery A., Marcus Textor, Donald L. Elbert, Stephanie Finken, Rolf Hofer, Nicholas D. Spencer, Laurence Ruiz-Taylor. "Multifunctional Polymeric Surface Coatings in Analytic and Sensor Devices." Patent US6884628 B2. Apr. 26, 2005 (granted). Sept. 12, 2002 (published).
- Anderson, Janelle R., Daniel T. Chiu, Noo-Li Jeon, Sui Huang, Ravi Kane, Insung S. Choi, Donald E. Ingber, George M. Whitesides. "Patterning of Surfaces Utilizing Microfluidic Stamps Including 3-D Arrayed Channel Networks." Patent US20040121066 A1. June 24, 2004 (published).
- Wilson, Wilbur, Charles Henry, Carlos Garcia. "A Microfluidic Device for Monitoring Biomolecular Interactions." Patent WO2004033098 A2. Apr. 22, 2004 (published).
- Wilson, Wilbur W., Charles S. Henry, Carlos D. Garcia. "Micro-Fluidic Device for Monitoring Biomolecular Interactions." Patent US20040067577 A1. Apr. 08, 2004 (published).
- Anderson, Janelle R., Oksana Cherniavskaya, Daniel T. Chiu, Rebecca J. Jackman, Cooper McDonald, George M. Whitesides. "Microfluidic System Including 3-D Arrayed Channel Networkd." Patent US6645432 B1. Nov. 11, 2003 (granted).
- Hammerick, Kyle, Friedrich B. Prinz, Robert Lane Smith, Ralph S. Greco, Rainer Fasching. "Device and Method for 3-D Spatial Localization and Functional Interconnection of Different Types of Cells." Patent US20020173033 A1. Nov. 21, 2002 (published).
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