A Novel Generic Platform for Chemical Patterning of Surfaces.

Author(s): Lussi, Jost W., Roger Michel, Ilya Reviakine, Didier Falconnet, Andreas Goessl, Gabor Csucs, Gaudenz Danuser, Jeffrey A. Hubbell, Marcus Textor

Journal: Prog. Surf. Sci. (2004) 76: 55-69.

Abstract:
A number of methods in biosensing and high-throughput screening rely on spatially addressable deposition and manipulation of biological moieties with high spatial fidelity. Since miniaturization and parallelization offer considerable practical and technical advantages, increasingly smaller structures with controllable biochemical properties are sought, such as micro- and nanoarrays of proteins and oligonucleotides. In studies of cell biology and implant-host response, a detailed understanding of how surface structures of biomaterials translate into specific cellular responses is another important area of investigation that benefits from well-defined patterns containing biological functionality at length scales comparable to those of substructures present on the surfaces of cells, i.e. the micrometer and sub-micrometer range.