Covalent Attachment of Novel Poly(ethylene glycol)-Poly(DL-lactic acid) Copolymeric Micelles to TiO₂ Surfaces

Author(s): Huang, Ning-Ping, Gabor Csucs, Kazunori Emoto, Yukio Nagasaki, Kazunori Kataoka, Marcus Textor, Nicholas D. Spencer

Journal: Langmuir (2002) 18: 252-258.

Abstract:
 We have investigated the attachment of recently developed poly(ethylene glycol)-poly(DL-lactic acid) (PEG-PLA) copolymeric micelles onto functionalized TiO₂ and Au. The attachment and immobilization of the micelles were investigated via X-ray photoelectron spectroscopy and reflection-absorption infrared spectroscopy. Protein resistance of the micelle-covered surfaces was tested with optical waveguide lightmode spectroscopy (OWLS). Our results suggest that these PEG-PLA micelles remain stable on the model surface and form a slightly flattened micelle layer with 70% surface coverage. The OWLS studies using human serum albumin as a model protein show that the micelle layer can enhance the protein resistance of the surfaces by up to 70%.