Ligand-Specific Targeting of Microspheres to Phagocytes by Surface Modification with Poly(L-Lysine)-Grafted Poly(Ethylene Glycol) Conjugate.

Author(s): Faraasen, Sofia, János Vörös, Gábor Csúcs, Marcus Textor, Hans P. Merkle, Elke Walter

Journal: Pharm. Res. (2003) 20(2): 237-246.

Abstract:
The purpose of this study was to demonstrate specific receptor-mediated targeting of phagocytes by functional surface coatings of microparticles, shielding from nonspecific phagocytosis and allowing ligand-specific interactions via molecular recognition.