Title: Patterned Biological Molecules on Inner Surface of Enclosed Tubes

Author(s): Orth, Reid N., Harold G. Craighead, Stephen W. Turner

Entity: N/A

Patent Number: US20030153010 A1. Published: Aug. 14, 2003.

Abstract:
Biomolecular photo-based patterning methods utilize avidin- biotin technology to immobilize functional proteins on the inner surface of silica glass tubes in desired patterns. The methods are useful for nanofluidic affinitybiosensor/chromatography systems and on silicon dioxide substrates for biosensor applications. The resulting patterns are optimized based on the application. A zebra shaped pattern is utilized for an affinity chromatography system.